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. 2016 Oct 15;7(50):82972–82984. doi: 10.18632/oncotarget.12690

Figure 7. Knockdown of 14-3-3ζ suppressed tumor growth and decreases the formation of metastases in vivo.

Figure 7

A. Knockdown of 14-3-3ζ remarkably reduced the volumes of tumor mass. Volumes of tumors formed by NCI-H520/shcontrol or NCI-H520/sh14-3-3ζ1 stable clones in nude mice were measured. Left shows the gross view of isolated tumors. Right shows the mean ±SD (n = 6) from each group at each time point. B. The number of metastatic nodules in the lung was decreased in the sh14-3-3ζ group compared to the sh-control group. C. Images of representative lung metastasis in the different groups. D. sh-14-3-3ζ could significantly decrease the expression of TGFβR1 in vivo.