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. 2016 Nov 15;7(50):83040–83050. doi: 10.18632/oncotarget.13349

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Copyright: © 2016 Zeng et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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(A) Kaplan-Meier plots of overall survival for BALB/c nude mice engrafted with CCRF cells for ALL (Left) and U937 cells for AML (Right). (B) Flow cytometry analysis of peripheral blood and bone marrow from CCRF-engrafted mouse model for the presence of leukemic cells (human CD45⁺). Data for U937 were not shown. (C) Representative images for bone marrow smear of U937-engrafted mouse model. U937 cells are bigger in size than the normal bone marrow cells. (D) Correlation of morbidity with the presence of leukemic cells in peripheral blood and bone marrow of CCRF and U937-engrafted mouse models. Ctl: control; Mdl: model; BM: bone marrow.