Figure 8. Crambescidin 816 induces tumor regression in an in vivo colorectal carcinoma model.

A. In vivo anticancer activity of C816 in a human tumor xenograft model. Representative Z-projection images of the tumor development in control and treated embryos after 48 h. B. Three-dimensional reconstruction of tumor development in control and treated embryos after 48 h. C. Tumor fluorescence intensities (mean ± SEM) and percentages of decrease in tumor volumes of treated embryos after 48 h. D. Survival rates of control and treated embryos (median and Q₁, Q₃). *Significant difference with respect to controls (p <0.05).