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. 2016 Nov 4;7(50):83115–83133. doi: 10.18632/oncotarget.13073

Figure 9. Concurrent and independent genomic alterations between the AR gene and the MUC1 genes network.

Figure 9

Gene amplification (red slot), deep deletion (blue slot), missense mutation (green square), inframe mutation (brown square), and truncating mutation (black square) in the AR gene and those genes in the MUC1 network were extracted from the CRPC and metastatic PC dataset within cBioPortal [44, 45]. A. The top row demonstrates pathologies for individual CRPC: red for CRPC adenocarcinoma (CRPC Ad); blue for neuroendocrine PC (NE); and orange for CRPC adenocarcinoma mixed with NEPC. CRPC cases bordered by two dot lines have genomic changes only in the MUC1 network. B. Genomic alterations in the AR gene and the MUC1 network in a metastatic PC cohort.