Figure 4. miR-181c expression and neuroblastoma patients' overall survival (OS).

Lower expression of miR-181c is related with a worse OS, either A. in the whole cohort of neuroblastoma samples or B. in only no amplified MYCN cases. Reduced expression of miR-181c is not significantly associated to a worse prognosis when considering the whole cohort of patients who undergo tumor progression event C. this relationship is significant when considering only the cases that progress and have no amplification of MYCN D. The cut off modus for miR-181c expression to draw Kaplan-Meier curves derives from the scan setting.