Table 2. Percentage of methylation of CpG islands, before (control) and after 5′-AZA treatment.
miR-29a | miR-34b/c | miR-126 | miR-181c/d | miR-200c/141 | miR-202 | miR-517a | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
NB cell lines | Control (%) | 5'Aza (%) | Control (%) | 5'Aza (%) | Control (%) | 5'Aza (%) | Control (%) | 5'Aza (%) | Control (%) | 5'Aza (%) | Control (%) | 5'Aza (%) | Control (%) | 5'Aza (%) |
ACN | 85 | 80 | 44 | 38 | 46 | 43 | 59 | 47 | 84 | 70 | 34 | 35 | 80 | 78 |
GI-ME-N | 90 | 73 | 88 | 79 | 84 | 66 | 94 | 62 | 86 | 65 | 88 | 66 | 96 | 77 |
SK-N-BE(2)-C | 89 | 73 | 93 | 76 | 48 | 39 | 88 | 60 | 89 | 60 | 88 | 73 | 90 | 80 |
SK-N-SH | 85 | 60 | 56 | 44 | 34 | 25 | 87 | 52 | 86 | 54 | 85 | 53 | 88 | 66 |
SH-SY5Y | 84 | 58 | 13 | 10 | 86 | 53 | 92 | 49 | 96 | 54 | 74 | 60 | 95 | 72 |
p-value | 0.009 | 0.02 | 0.05 | 0.004 | 0.004 | 0.04 | 0.02 |