Table 2. Surface expression of CD19 and EC50 values for RDL by SPM-1 with different malignant B lymphoid cell lines as targets.
Cell Line | Subtype of malignancy | CD19 density [#] | EC50 (range) [pM] |
---|---|---|---|
SEM | Pro-B (mixed lineage) | 42,600 ± 10,700 | 5.6 (2.5 – 10) |
NALM-6 | Pre-B | 26,700 ± 11,400 | 6.1 (1.8 – 17.3) |
RAJI | Burkitt's Lymphoma | 31,900 ± 22,800 | 16.5 (5.4 – 38.5) |
ARH-77 | Mature B (myeloma) | 2,400 ± 1,200 | 79.4 (38 – 645.3) |
Antigen densities are given in copy numbers per cell.