Table 4. Results From a Meta-Analysis of the Association Between coronary heart disease or restenosis after PCI and the Heme oxygenase-1 gene promoter polymorphism.
| Polymorphism and Subgroup | No. of Studies | No. of Cases | No. of Controls | Genotype | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| S/L | SS/SL+LL | SS+SL/LL | SL/LL | SS/LL | |||||||||
| OR and 95%CI | P Value | OR and 95%CI | P Value | OR and 95%CI | P Value | OR and 95%CI | P Value | OR and 95%CI | P Value | ||||
| (GT)n polymorphism with CHD | |||||||||||||
| Total | 13 | 7835 | 5372 | 0.929(0.881, 0.978) | 0.005 | 0.858(0.780, 0.945) | 0.002 | 0.937 (0.867, 1.012) | 0.100 | 0.963(0.888, 1.045) | 0.369 | 0.843 (0.754, 0.942) | 0.003 |
| Caucasian | 6 | 3492 | 1633 | 1.019 (0.927, 1.119) | 0.701 | 1.033(0.840, 1.271) | 0.759 | 1.020 (0.901, 1.154) | 0.756 | 1.015(0.892, 1.156) | 0.818 | 1.042(0.838, 1.296) | 0.709 |
| Asian | 7 | 4343 | 3739 | 0.891 (0.837, 0.949) | 0.000 | 0.815(0.731, 0.909) | 0.000 | 0.887 (0.803, 0.980) | 0.018 | 0.931(0.838, 1.034) | 0.180 | 0.781(0.686, 0.890) | 0.000 |
| Good quality | 6 | 6373 | 3964 | 0.915 (0.863, 0.971) | 0.003 | 0.830 (0.746, 0.924) | 0.001 | 0.929 (0.849, 1.017) | 0.110 | 0.964(0.877, 1.060) | 0.551 | 0.822(0.726, 0.930) | 0.002 |
| Poor quality | 7 | 1462 | 1408 | 0.959 (0.856, 1.074) | 0.468 | 0.995 (0.795, 1.246) | 0.976 | 0.960 (0.824, 1.117) | 0.595 | 0.961(0.819, 1.127) | 0.623 | 0.935(0.728, 1.201) | 0.599 |
| (GT)n polymorphism with restenosis | |||||||||||||
| Total | 6 | 972 | 4052 | 0.718 (0.541, 0.953) | 0.022 | 0.674 (0.425, 1.069) | 0.093 | 0.662(0.434, 1.010) | 0.056 | 0.877(0.740, 1.039) | 0.130 | 0.522(0.306, 0.889) | 0.017 |
| Caucasian | 4 | 843 | 3813 | 0.766 (0.557, 1.053) | 0.100 | 0.870 (0.637, 1.190) | 0.384 | 0.694 (0.400, 1.204) | 0.194 | 0.742 (0.439, 1.254) | 0.265 | 0.72 (0.384, 1.380) | 0.330 |
| Asian | 2 | 129 | 239 | 0.590 (0.430, 0.809) | 0.001 | 0.755(0.065, 0.737) | 0.022 | 0.572 (0.361, 0.907) | 0.018 | 0.689 (0.426, 1.115) | 0.130 | 0.548(0.461, 0.660) | 0.003 |
| Meeting HWE | 4 | 548 | 3023 | 0.679(0.446, 0.934) | 0.041 | 0.553(0.230, 1.327) | 0.184 | 0.664(0.381, 1.156) | 0.148 | 0.740(0.435, 1.258) | 0.266 | 0.414(0.195, 0.879) | 0.022 |
| Deviating from HWE | 2 | 424 | 1029 | 0.693(0.296, 1.620) | 0.397 | 0.959(0.667, 1.380) | 0.822 | 0.554(0.151, 2.034) | 0.373 | 0.566(0.158, 2.209) | 0.382 | 0.684(0.192, 2.434) | 0.557 |
| T(−413)A polymorphism with CHD | A/T | AA/AT+TT | AA+AT/TT | AT/TT | AA/TT | ||||||||
| Total | OR and 95%CI | P Value | OR and 95%CI | P Value | OR and 95%CI | P Value | OR and 95%CI | P Value | OR and 95%CI | P Value | |||
| 4 | 3323 | 4757 | 0.915(0.842, 0.995) | 0.038 | 0.869(0.760, 0.994) | 0.041 | 0.907(0.788, 1.045) | 0.177 | 0.958(0.826, 1.110) | 0.567 | 0.792(0.663, 0.946) | 0.010 | |