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A. Haematoxylin and eosin (H&E) staining of pituitary adenomas(40×). B. The Ki-67 index was greater than 10% (40×). C. Immunohistochemistry for p53 showing very few immunopositive cells (3 %) (40×). D. The proportion of ACTH-positive tumor cells in resected tissue increased as operation frequency increased (40×).
