Table 3. Associations between GAS5 rs145204276 and CRC susceptibility stratified by Tumor site.
| Genotypes | Cases (n, %) | Controls (n, %) | OR (95% CI)a | Ptrend |
|---|---|---|---|---|
| Colon | ||||
| ins/ins | 428 (53.1%) | 639 (45.6%) | 1.00 (Reference) | |
| ins/del | 313 (38.8%) | 610 (43.6%) | 0.77 (0.64-0.92) | |
| del/del | 65 (8.1%) | 151 (10.8%) | 0.64 (0.47-0.88) | |
| del vs ins | 0.78 (0.68-0.90) | 4.56×10−4 | ||
| Rectum | ||||
| ins/ins | 310 (52.2%) | 639 (45.6%) | 1.00 (Reference) | |
| ins/del | 237 (39.9%) | 610 (43.6%) | 0.80 (0.65-0.98) | |
| del/del | 47 (7.9%) | 151 (10.8%) | 0.64 (0.45-0.91) | |
| del vs ins | 0.80 (0.69-0.93) | 3.80×10−3 |
a
adjusted by age, gender, alcohol and smoking status