Table 2.

Comparison between siRNA delivery methods.

Method	Advantages	Drawbacks
Chemical or enzymatic synthesis	Rapid Enzymatic: no need to test individual siRNA Chemical: high purity	Transient RNAi Needs transfection Enzymatic: variable purity & specificity Chemical: expensive
DNA plasmid vector or casette	Less expensive Stable RNAi	Labor intensive Needs transfection
Viral vector	Stable RNAi May be effective in cells resistant to transfection with dsRNA/plasmids	Labor intensive Potential biohazard