Table 4.

Association of explanatory variables with probability to experience an at least 50% reduction in symptom scores after first drug dose (irrespective of using 1 or 2 tablets). For purpose of analysis, the reference group was defined as males, starting treatment on day 1 of symptom manifestation with an initial dose of one tablet; data for age and body weight are per 10 year or 10 kg increments, respectively, data for baseline score per point at baseline. Data are shown as odds ratio for more than 50% improvement with 95% confidence intervals in square brackets. The percentage of overall participants showing an at least 50% improvement per score is shown in the main text. Odds ratios greater 1 indicate a greater probability of success, odds ratios below 1 a smaller probability being associated with the respective explanatory variable

Explanatory variable	TIRS	TPRS	NSS	TSS
Female gender	0.856 [0.638–1.145]	0.970 [0.746–1.261]	0.828 [0.634–1.082]	0.949 [0.729–1.235]
Age	1.067 [0.977–1.166]	1.122 [1.037–1.214]	1.093 [1.008–1.186]	1.092 [1.009–1.183]
Body weight	0.944 [0.861–1.036]	0.920 [0.846–1.001]	0.934 [0.857–1.018]	0.954 [0.877–1.039]
Baseline score	0.896 [0.850–0.944]	1.024 [0.978–1.072]	0.925 [0.873–0.979]	0.874 [0.822–0.930]
Start of treatment day 2	0.785 [0.588–1.042]	0.904 [0.703–1.161]	0.725 [0.559–0.939]	0.823 [0.635–1.062]
Start of treatment day 3	0.740 [0.529–1.034]	0.588 [0.436–0.791]	0.570 [0.418–0.775]	0.556 [0.411–0.750]
Start of treatment day 4	0.636 [0.354–1.171]	0.419 [0.236–0.729]	0.498 [0.281–0.871]	0.346 [0.198–0.596]
Start of treatment day 5	1.436 [0.612–3.949]	0.587 [0.293–1.164]	1.150 [0.576–2.354]	0.867 [0.434–1.790]
Two tablets at 1st dose	1.396 [1.094–1.778]	1.435 [1.150–1.792]	1.413 [1.126–1.774]	1.603 [1.285–2.000]