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. 2017 Mar 7;17(5):1600213. doi: 10.1002/pmic.201600213

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© 2017 Proteomics Published by Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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PCA scores plot of principal components 1 and 3. Microdissected samples clustered according to their histology, with principal component 1 discriminating between stroma and epithelium and principal component 3 discriminating between malignancy, on the basis of expression of immune regulatory proteins. Red filled squares: microdissected infiltrate from malignant tumor sections; black filled circles: microdissected malignant tumor epithelium; orange filled circles: microdissected ductal carcinoma in situ epithelium; blue filled circles: microdissected epithelial cells from fibroadenoma sections; green filled circles: microdissected epithelial cells from histologically normal sections. Black circles: stroma dissected from histologically malignant sections; blue circles: stroma dissected from a fibroadenoma section; orange circles: stroma dissected next to ductal carcinoma in situ lesions; green circles: stroma dissected from histologically normal sections.