Table 4.
Biological variation indices for all biomarkers in healthy subjects
| CVa | CVi | CVg | II | RCV (%) | Log normal | ||
|---|---|---|---|---|---|---|---|
| RCV up | RCV down | ||||||
| Established biomarkers | |||||||
| NT‐proBNP | 3.3 | 25.1 | 54.0 | 0.5 | 70.7 | 107.0 | −48.2 |
| hsTnT | 1.5 | 16.0 | 51.2 | 0.3 | 44.9 | 83.4 | −27.0 |
| Novel biomarkers | |||||||
| Galectin‐3 | 3.2 | 8.1 | 21.0 | 0.4 | 24.6 | 28.5 | −21.3 |
| GDF‐15 | 15.2 | 18.9 | 47.6 | 0.5 | 69.9 | 113.3 | −43.1 |
| ST2 | 2.9 | 10.5 | 30.4 | 0.4 | 31.9 | 40.9 | −25.0 |
| Renal/neurohormonal biomarkers | |||||||
| Creatinine | 1.6 | 4.1 | 14.4 | 0.3 | 12.4 | 13.3 | −11.5 |
| Plasma renin concentration | 2.3 | 30.1 | 41.6 | 0.7 | 83.8 | 154.1 | −50.7 |
| Aldosterone | 6.2 | 36.6 | 34.7 | 1.1 | 104.2 | 199.6 | −58.9 |
| Phosphate | 1.3 | 6.9 | 8.2 | 0.9 | 19.8 | 22.0 | −17.6 |
| PTH | 1.1 | 16.7 | 39.8 | 0.4 | 46.3 | 63.5 | −34.8 |
| hsTnT (n = 5) | 4.4 | 19.8 | 56.8 | 0.4 | 57.0 | 78.7 | −41.7 |
| Electrolytes | |||||||
| Calcium | 1.5 | 1.7 | 3.2 | 0.7 | 6.6 | 5.0 | −4.8 |
| Sodium | 0.7 | 1.9 | 2.3 | 1.6 | 5.9 | 4.8 | −4.5 |
CVa, analytical coefficient of variation; CVg, interindividual coefficient of variation; CVi, intraindividual coefficient of variation; GDF‐15, growth differentiation factor 15; hsTnT, high‐sensitivity troponin T; II, index of individuality; PTH, parathyroid hormone; RCV, reference change value; ST2, suppression of tumorigenicity 2.