Figure 8.

Ultrasound sequences demonstrating steps used to lyse SonoVue® microbubbles on each occasion, prior to repeating an injection of SonoVue®. B‐mode (on right) and contrast enhanced (on left) ultrasound images of the kidney. (a) Post‐injection of IV SonoVue® in contrast enhanced ultrasound mode (probe frequency is 4 Hz) image shows echogenicity of perfused renal parenchyma. (b) Probe frequency in the process of being increased from 4 to 8.5 Hz. This process increases the mechanical index (MI) of the ultrasound waves to intentionally disrupt the SonoVue® microbubbles. The MI is seen to change from 0.18 (6(a)) to 1.9 (6(b) and 6(c)). (c) With the higher frequency (8.5 Hz) the contrast ultrasound mode is non‐operational and both left and right images from the split screen show a B‐mode ultrasound image