Table 2.

Statistical results of interaction effect between RLE and CNR1 gene haplotype tag SNPs in the total study population

	SNP	A1	Possible migraine				Headache with nausea				Headache with photophobia				Headache with disability
			OR	L95	U95	P	OR	L95	U95	P	OR	L95	U95	P	OR	L95	U95	P
1	rs2180619	G	1.006	0.908	1.115	0.904	0.922	0.834	1.021	0.118	1.000	0.904	1.106	0.999	1.021	0.923	1.130	0.687
2	rs806379	T	0.969	0.877	1.071	0.537	1.012	0.917	1.117	0.811	0.910	0.825	1.004	0.061	1.007	0.912	1.112	0.893
3	rs1535255	G	0.919	0.808	1.044	0.195	0.939	0.828	1.065	0.326	0.963	0.850	1.093	0.562	0.966	0.851	1.097	0.594
4	rs2023239	C	0.931	0.816	1.062	0.287	0.935	0.822	1.063	0.302	0.985	0.867	1.120	0.820	1.000	0.878	1.138	0.994
5	rs806369	T	1.085	0.967	1.217	0.166	1.123	1.002	1.259	0.045	1.090	0.974	1.221	0.134	1.086	0.970	1.217	0.154
6	rs1049353	A	0.885	0.789	0.993	0.037	0.846	0.755	0.948	0.004	0.965	0.863	1.079	0.531	0.915	0.817	1.024	0.123
7	rs4707436	A	0.892	0.796	1.001	0.051	0.860	0.767	0.963	0.009	0.981	0.877	1.097	0.737	0.928	0.829	1.039	0.196
8	rs12720071	G	1.003	0.833	1.209	0.974	0.980	0.816	1.178	0.832	0.944	0.786	1.132	0.531	0.933	0.780	1.115	0.447
9	rs806368	C	1.010	0.896	1.139	0.873	0.943	0.838	1.061	0.327	0.985	0.876	1.107	0.797	0.974	0.865	1.096	0.661
10	rs806366	T	0.884	0.791	0.987	0.028	0.819	0.733	0.916	0.0005 *	0.959	0.862	1.066	0.438	0.896	0.804	0.999	0.048
11	rs7766029	T	1.111	1.001	1.232	0.047	1.114	1.006	1.234	0.038	1.079	0.976	1.194	0.139	1.103	0.996	1.222	0.060

Possible migraine: 2 or 3 migraine related symptoms measured by the ID‐Migraine screening questionnaire.

Bold, nominally significant effects; italic, trend effects; L95‐U95, 95% confidence interval; OR, odds ratio; P, significance.

^*Remained significant after false discovery rate correction of multiple testing.