Table 1.

Lentiviral vector integration profiles within genes and near transcription start sites^a.

Distance to genes or TSS	Integration frequency (%) of the reference set (n=1,000,000)	Integration frequency (%) of the target set (n=874)	P value
Within genes	44.61 (446080)	49.77 (435)	0.002**
Introns	42.12 (421233)	46.80 (409)	0.005**
Exons	2.48 (24847)	2.97 (26)	0.352
Within +5 kb of TSS	6.18 (61849)	8.01 (70)	0.025*
Within −5 kb of TSS	4.24 (42405)	5.03 (44)	0.244
Within ±5 kb of TSS	10.43 (104254)	13.04 (114)	0.011*
Within +50 kb of TSS	44.61 (446080)	49.77 (435)	0.002**
Within −50 kb of TSS	25.22 (252156)	33.98 (297)	0.000**
Within ±50 kb of TSS	69.82 (698236)	83.75 (732)	0.000**
Within +5 kb ~ +50 kb of TSS	38.42 (384231)	41.76 (365)	0.042*
Within −5 kb ~ −50 kb of TSS	20.98 (209751)	28.95 (253)	0.000**

^aDifferent distances to the transcriptional start sites (TSS);

‘+’ – downstream of TSS, ‘−’ – upstream of TSS.

^*Represented a significant difference (P<0.05) for the χ² test as compared with the reference set.

^**Represented a significant difference (P<0.01) for the χ² test as compared to the reference set.