Table 1. Baseline demographic status and comorbidity compared between comparison and migraine cohorts.
| Variable | Migraine-free cohort N = 90784 (%) | Migraine cohort N = 22696 (%) | Standardized mean difference |
|---|---|---|---|
| Age, years (SD) | 44.5 (16.4) | 44.5 (14.9) | 0.002 |
| Sex | 0.029 | ||
| Female | 66862 (73.6) | 16422 (72.4) | |
| Male | 23922 (26.4) | 6274 (27.6) | |
| Comorbidity | |||
| Hypertension | 23335 (25.7) | 6013 (26.5) | 0.018 |
| DM | 6434 (7.09) | 1699 (7.49) | 0.015 |
| CAD | 14372 (15.8) | 3700 (16.3) | 0.013 |
| Stroke | 1911 (2.10) | 497 (2.19) | 0.006 |
| Epilepsy | 892 (0.98) | 237 (1.04) | 0.006 |
| Head injury | 6151 (6.78) | 1629 (7.18) | 0.016 |
| RLS | 113 (0.12) | 27 (0.12) | 0.002 |
| Depression | 7985 (8.80) | 2041 (8.99) | 0.007 |
| Dementia | 472 (0.52) | 123 (0.54) | 0.003 |
| Asthma | 7902 (8.70) | 2051 (9.04) | 0.012 |
| COPD | 10823 (11.9) | 2781 (12.3) | 0.010 |
| Medicine | |||
| Migraine prophylaxis | 38321 (42.2) | 16293 (71.8) | 0.626 |
Migraine prophylaxis including amitriptyline, clomipramine, duloxetine, flunarizine, fluoxetine, gabapentin, imipramine, paroxetine, sertraline, topiramate, valproate, venlafaxine and beta blockers.
Abbreviation: DM: diabetes mellitus; CAD: coronary arterial disease; RLS: restless leg syndrome; COPD, chronic obstructive pulmonary disease