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. 2004 Nov 11;5(1):21. doi: 10.1186/1465-9921-5-21

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Copyright © 2004 Vissers et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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The suppression of OVA-specific IgE in serum by ISS-ODN-stimulated and OVA-loaded Mφ is partially mediated by IL-10. Sensitized mice were treated (i.v.) with saline (sham), ISS-ODN-stimulated OVA-Mφ (ISS-ODN/OVA-Mφ), ISS-ODN-stimulated IL-10^-/-Mφ (ISS-ODN/IL10^-/-Mφ), or ISS-ODN-stimulated IL-10^-/-OVA-Mφ (ISS-ODN/IL10^-/-OVA-Mφ). Serum OVA-specific IgE levels were measured prior to and after OVA challenge. Values are expressed as the mean ± SEM (n = 6 to 8 per group). *P < .05 compared with sham-treated and OVA-challenged mice. ^†P < .05 compared with mice treated with ISS-ODN/IL10^-/-OVA-Mφ and that were OVA-challenged.