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. 2017 Mar 13;12(3):e0173494. doi: 10.1371/journal.pone.0173494

Fig 4. CX5461-induced nucleolar disruption was not attenuated upon disassembly of paraspeckles by depleting essential protein components.

Fig 4

A. Western analysis of protein reduction by corresponding siRNAs. B. Depletion of the selected paraspeckle proteins has no effect on nucleolar localization of fibrillarin in the presence of DMSO. C. Depletion of the selected paraspeckle proteins failed to rescue the CX5461-induced mislocalization of fibrillarin to nucleoplasm.