Skip to main content
. 2017 Feb 27;13(2):e1006623. doi: 10.1371/journal.pgen.1006623

Fig 5. Ribosome accumulation in 5’UTR correlates with translational repression of target genes.

Fig 5

(A-C) Ribosome accumulation in 5’UTRs of ribo-upregulated TKO targets in WT B cells (A), ribo-downregulated TG targets in TG B cells (B), but not in 5’UTRs of other targets (C). Ribosome occupancy in 5’UTR was normalized to the overall ribosome footprint abundance of the same gene [96]. The first nucleotide of start codon is set as position 0 (grey dashed line). (D) Inverse correlation between ribosome occupancy in 5’UTR and the overall ribosome density on target mRNA in WT B cells. (E) High GC content in 5’UTRs of ribo-upregulated TKO targets.