Table 3.

Association of biliary enzyme with OS in patients with intrahepatic cholangiocarcinoma (N=173)

Variables	Group	Case number	HR (95% CI)	P-value	Adjusted HR (95% CI)	Adjusted P-value
ALB	<40.7/≥40.7	84/89	0.654 (0.466–0.917)	0.014	0.741 (0.521–1.053)	0.095
ALP	<138/≥138	86/87	1.818 (1.290–2.560)	0.001	1.654 (1.170–2.337)	0.004
TBIL	<12.2/≥12.2	85/88	1.692 (1.198–2.389)	0.003	1.624 (1.142–2.310)	0.007
DBIL	<4.7/≥4.7	86/87	1.984 (1.403–2.804)	<0.0001	1.856 (1.304–2.642)	0.001
GGT	<113/≥113	85/88	1.804 (1.281–2.540)	0.001	1.641 (1.160–2.321)	0.005
Chemotherapy	5-fluorouracil-based/gemcitabine-based	74/99	1.277 (0.902–1.808)	0.148	1.290 (0.914–1.821)	0.168

Note: Analysis was adjusted for CA19-9 (<1,000 vs ≥1,000) variables identified by multivariate Cox regression analyses.

Abbreviations: OS, overall survival; HR, hazard ratio; CI, confidence interval; ALB, albumin; ALP, alkaline phosphatase; TBIL, total bilirubin; DBIL, direct bilirubin; GGT, gamma glutamyltranspeptidase.