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. 2017 Mar 6;10:1423–1431. doi: 10.2147/OTT.S118366

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© 2017 Chen et al. This work is published and licensed by Dove Medical Press Limited

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High expression of miR-543 inhibits cell proliferation, induces cell apoptosis and blocks cell cycle.

Notes: (A) miR-543 overexpression and knocking down cell models were established successfully. (B) Cell proliferation was inhibited when miR-543 was overexpressed. (C) The capability of clone formation was restrained in miR-543 mimics group. (D) Cell apoptosis rate was increased in miR-543 mimics group. (E) Cell cycle was suppressed when miR-543 was overexpressed. (F) Protein expression level of CyclinD1 and Bcl-2 was downregulated and BAX was increased in miR-543 mimics group. n=5, *P<0.05, **P<0.01 vs control or NC group.

Abbreviation: NC, nitrocellulose.