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. 2017 Mar 6;10:1423–1431. doi: 10.2147/OTT.S118366

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© 2017 Chen et al. This work is published and licensed by Dove Medical Press Limited

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The effect of miR-543 on breast cancer was achieved through the regulation of MAPK/ERK signal pathway.

Notes: (A) The activity of MAPK/ERK was detected by Western blot. (B) Chemotherapy resistance was suppressed in miR-543 mimics group. (C) Inhibited clone formation in miR-543 mimics group. (D) Cell apoptosis tested by flow cytometry. (E) Cell cycle results tested by flow cytometry. (E) The protein level of CyclinD1, Bcl-2 and BAX was measured by Western blot. n=5, *P<0.05, **P<0.01 vs mimics NC group or as marked in the figure.

Abbreviations: ERK, extracellular signal-regulated kinase; MAPK, mitogen-activated protein kinase; NC, nitrocellulose.