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. 2017 Mar 7;12:1827–1840. doi: 10.2147/IJN.S130539

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© 2017 Zhang et al. This work is published and licensed by Dove Medical Press Limited

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In vivo chemophotothermal therapy of tumor by using Dox@PAH-cit/PDA NPs. (A) The blood circulation of Dox@PAH-cit/PDA NPs. (B) Fluorescence images of the tumor and main organs of PC3 xenograft tumor-bearing nude mice sacrificed at 24 h postinjection of PDA-Cy5.5 NPs and naked Cy5.5. (C) The biodistribution of PDA-Cy5.5 NPs or naked Cy5.5 measured at 24 h postinjection. (D) Photographs of the excised tumors of mice after sacrifice. (E) The tumor volume evolution of mice in different groups during the therapeutic period. (F) The body weight changes of mice during the therapeutic period. *P<0.05 and **P<0.01 were calculated by using Student’s t-test.

Abbreviations: Cy, Cyanine; Dox, doxorubicin; NIR, near-infrared reflection; NP, nanoparticle; PAH-cit, poly(allylamine)-citraconic anhydride; PBS, phosphate-buffered saline; PDA, polydopamine.