Table 4. Adjusteda associations of change in thyroid hormones levels in high versus low SG-corrected DPHP in all subjects and stratified by sex (51 subjects, 133 samplesb).
| Model | DPHPd | n | Total T4 (μg/dL)* | Free T4 ln(ng/dL) | Total T3 ln(ng/mL) | TSH ln(mIU/mL) |
|---|---|---|---|---|---|---|
| βeta (95% CI)e | eβeta (95% CI)f | eβeta (95% CI)f | eβeta (95% CI)f | |||
| Allc | Low | 89 | 0.00 (Ref) | 1.00 (Ref) | 1.00 (Ref) | 1.00 (Ref) |
| High | 44 | 0.43 (0.15, 0.72) | 1.01 (0.97, 1.05) | 1.03 (0.98, 1.08) | 1.05 (0.90, 1.23) | |
| Women | ||||||
| Low | 39 | 0.00 (Ref) | 1.00 (Ref) | 1.00 (Ref) | 1.00 (Ref) | |
| High | 22 | 0.91 (0.47, 1.36) | 1.01 (0.95, 1.07) | 1.05 (0.98, 1.13) | 0.91 (0.71, 1.68) | |
| Men | ||||||
| Low | 50 | 0.00 (Ref) | 1.00 (Ref) | 1.00 (Ref) | 1.00 (Ref) | |
| High | 22 | 0.19 (-0.15, 0.52) | 1.02 (0.96, 1.08) | 1.04 (0.97, 1.11) | 1.06 (0.88, 1.27) | |
ln, natural logarithm; CI, confidence interval
a
All models adjusted for sampling round, time of sample collection (morning, afternoon, evening), SG-corrected iodine (μg/L), and BDE-47 (ng/g lipid).
b
1 sample excluded due to extreme urinary dilution (SG = 1.0001), 1 sample missing BDE-47 due to potential contamination.
c
Models additionally adjusted for sex.
d
“Low” <2.65 ng/mL, “High” ≥ 2.65 ng/mL
e
βeta represents the absolute mean difference in Total T4 in the high compared to low DPHP group
f
eβeta represents the relative mean difference hormone level in the high compared to low DPHP group
*
Sex*DPHP interaction p-value = 0.03