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. 2016 Nov 17;7(49):80298–80312. doi: 10.18632/oncotarget.13437

Figure 2. Expression of inflammatory cytokines is increased in exocrine glands from Smad4 tKO NOD mice.

Figure 2

(A and B) Total RNA and (C) tissue lysates were prepared from lacrimal and salivary glands of Smad4 tKO NOD and WT NOD mice at 12 weeks of age. The expression of mRNA for various cytokines (A) and transcription factors (B) was analyzed by qRT-PCR. Values are expressed as the relative fold-change as compared with WT. (C) IFN-γ and IL-17 production was measured by ELISA. Data are mean ± SD (n = 6~9/group). *P < 0.05, **P < 0.01.