Table 3. Multivariate analyses of variables in relation to five-year overall survival of all patients.

Variables	Parameter	Hazard ratio (95% CI)	p-value
Lauren classification	Diffuse vs. intestinal	1. 044 (0. 707–1. 544)	0. 827
Tumor stage	pT2-4 vs. pT1	0. 423 (0. 200–0. 895)	0. 024*
Lymph-node metastasis	Present vs. absent	0. 346 (0. 193−0. 621)	< 0. 001*
Lymphatic invasion	Present vs. absent	0. 581 (0. 390−0. 866)	0. 008*
Perineural invasion	Present vs. absent	0. 682 (0. 462−1. 005)	0. 053
PD-L1	High vs. low	0. 647 (0. 335−1. 250)	0. 195
PD1	High vs. low	1. 345 (0. 922−1. 963)	0. 124

^*Statistically significant p-values are indicated in boldface type.

Abbreviations: CI, confidence interval.