Table 2. Kaplan-Meier analysis of factors associated with OS and DFS in the entire cohort.
| Variable | Mean OS (month) | Median OS (month) | P | Mean DFS (month) | Median DFS (month) | P |
|---|---|---|---|---|---|---|
| Age (year) | 0.598 | 0.765 | ||||
| ≤ 57.0† | 65.6 | 54.0 | 59.7 | 40.0 | ||
| > 57.0 | 59.0 | 55.0 | 52.9 | 42.0 | ||
| Sex | 0.022 | 0.039 | ||||
| Female | 73.2 | NR | 67.2 | 74.0 | ||
| Male | 58.7 | 42.0 | 52.9 | 34.0 | ||
| Location | 0.128 | 0.267 | ||||
| Upper | 67.8 | 79.0 | 51.8 | 35.0 | ||
| Middle | 57.2 | 42.0 | 53.3 | 35.0 | ||
| Lower | 71.2 | NR | 64.9 | 55.0 | ||
| Differentiation | 0.017 | 0.006 | ||||
| Well | 63.4 | 64.0 | 60.3 | 66.0 | ||
| Moderate | 66.3 | 68.0 | 59.2 | 57.0 | ||
| Poor | 44.6 | 26.0 | 38.9 | 22.0 | ||
| pT status | 0.004 | 0.006 | ||||
| T1 | 58.2 | NR | 54.0 | NR | ||
| T2 | 71.1 | 74.0 | 67.4 | 77.0 | ||
| T3 | 59.1 | 40.0 | 51.9 | 29.0 | ||
| pN status | < 0.001 | < 0.001 | ||||
| N0 | 80.1 | NR | 72.8 | 90.0 | ||
| N1 | 47.5 | 40.0 | 44.0 | 29.0 | ||
| N2 | 27.5 | 16.0 | 23.4 | 12.0 | ||
| N3 | 21.2 | 11.0 | 12.6 | 9.0 | ||
| pTNM Stage | < 0.001 | < 0.001 | ||||
| I | 67.1 | NR | 65.6 | NR | ||
| II | 77.2 | NR | 69.7 | 83.0 | ||
| III | 35.0 | 21.0 | 31.1 | 17.0 | ||
| Surgery | 0.013 | 0.046 | ||||
| Unqualified | 47.4 | 32.0 | 44.8 | 26.0 | ||
| Qualified | 67.7 | 64.0 | 61.1 | 52.0 | ||
| KIF-2C | 0.036 | 0.038 | ||||
| <2.0 | 68.9 | 71.0 | 62.5 | 59.0 | ||
| ≥2.0 | 50.6 | 41.0 | 46.3 | 30.0 |
pT, Pathologic tumor; pN, Pathologic node; OS, Overall survival; DFS, Disease-free survival; NR: Not reached; Qualified surgery, R0 resection with at least 12 resected lymph nodes; Unqualified surgery, R0 resection with less than 12 resected lymph nodes.
†
Median age.