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. 2016 Nov 2;7(49):80586–80598. doi: 10.18632/oncotarget.13014

Figure 3. FTY720 inhibits migration in NPC cells.

Figure 3

(A) FTY720 suppresses cell migration in CNE-1 and CNE-2 cells. Images of wound healing assays were captured after 0, 24 and 48 h. (B, C) The inhibitory effect of FTY720 on cell migration was confirmed using transwell migration assays in CNE-1 and CNE-2 cells. The data are shown as the mean ± S.D. of three independent experiments. *P < 0.05. (D) The protein levels of MMP-2 and MMP-9 were evaluated using Western blot analysis in CNE-1 and CNE-2 cells that were treated with 5 μM FTY720 for 24 h. GAPDH was used as a loading control. FTY720 decreased the expression of MMP-2 and MMP-9 in NPC cells.