Figure 8. Ru1 inhibites the tumor progression of lung cancer in vivo.

(A) Athymic nude mice injected (s.c.) with A549 cells were injected with Ru1 (0, 10 or 20 mg/kg, i.p.). (B) The volume of tumors was monitored in terms of tumor volume every week. The weights of the mice tumors (C) and the body (D) were determined, (E) Immunohistochemical analysis of LC3-II, cleaved caspase-3, CD-31 and Ki-67 expression in tumor tissue. All images were representative and were taken at 200× magnification. Results were represented as mean ± SD (*p < 0.05, ***p < 0.001, compared with that of the untreated control).