Table 3. Diagnostic performance of individual genes, gene combinations and hrHPV detection in cervical scrapings of women referred with an abnormal smear (ranked on sensitivity CIN3+).
| specificity CIN0/1 | sensitivity | P˘ | |||
|---|---|---|---|---|---|
| CIN2+ | CIN3+ | (mi)Ca | |||
| Individual genes | |||||
| SOX1 | 88% | 59% | 71% | 80% | 5×10-15 |
| SOX14 | 88% | 50% | 60% | 69% | 8×10-11 |
| TBX20 | 97% | 40% | 52% | 58% | 2×10-12 |
| SLC6A5 | 98% | 28% | 36% | 51% | 4×10-10 |
| Gene combinations | |||||
| SOX1/SOX14/TBX20 | 84% | 63% | 76% | 83% | 8×10-15 |
| SLC6A5/SOX1/SOX14/TBX20 | 84% | 63% | 76% | 83% | 8×10-15 |
| SOX1/SOX14 | 84% | 63% | 75% | 83% | 1×10-14 |
| SLC6A5/SOX1/SOX14 | 84% | 63% | 75% | 83% | 1×10-14 |
| SOX1/TBX20 | 87% | 60% | 72% | 81% | 4×10-15 |
| SLC6A5/SOX1/TBX20 | 87% | 60% | 72% | 81% | 4×10-15 |
| SLC6A5/SOX1 | 87% | 58% | 71% | 81% | 1×10-14 |
| SOX14/TBX20 | 88% | 53% | 64% | 69% | 2×10-11 |
| SLC6A5/SOX14/TBX20 | 88% | 53% | 64% | 69% | 2×10-11 |
| SLC6A5/SOX14 | 88% | 50% | 60% | 69% | 8×10-11 |
| SLC6A5/TBX20 | 97% | 40% | 52% | 58% | 2×10-12 |
| hrHPV detection | |||||
| GP5+/6+ and Cobas | 42% | 80% | 80% | 72% | 5×10-3 |
˘
linear-by-linear association test.