Table 1. Multivariate analysis using the forward stepwise Cox regression procedure.

Variables	Univariatea	Multivariateb
	p-value	HR	95% CI	p value
Age (years)
≥ 60 vs < 60	0.0306*			0.2006
Gender
Female vs Male	0.8376			0.5985
Edmondson–Steiner grade
G1-2 vs G3-4	0.3593			0.2302
TNM stage
I–II vs III–IV	0.1141	1.9232	1.0347–3.5748	0.0387*
AFP level (ng/ml)
≥ 400 vs < 400	0.7592			0.6320
Alcohol consumption
Yes vs No	0.3093			0.2393
HBV/HCV infection
Yes vs No	0.0060*			0.6725
Vascular invasion
None vs Micro/macro	0.3129			0.1351
miR-33b expression
High vs low	0.0070*			0.0871
miR-9-1 expression
High vs low	< 0.0001*	4.1143	2.1100–8.0225	< 0.0001*
miR-9-2 expression
High vs low	< 0.0001*	3.6734	1.856–7.2687	< 0.0001*
miR-21 expression
High vs low	0.0054*			0.2933
miR-22 expression
High vs low	0.0411*	0.4584	0.2514–0.8359	0.0109*
miR-223 expression
High vs low	0.0421*			0.3171
miR-139 expression
High vs low	0.0099*			0.7177

Abbreviations: CI = confidence interval; HR = harzard ratio.

^*p value less than 0.05 with significant difference between two groups.

^athe Kaplan-Meier method, and significance was determined by log-rank test.

^bmultivariate survival analysis was performed using Cox proportional hazard model.