Table 4. The frequencies of estimated haplotypes between patients and controls and their risk prediction for HCC risk with and without adjusting for potential confounders.

Haplotype	Patients	Controls	P	OR (95% CI)	P	OR (95% CI)	P*
A-T-C-C-G-G-T-A	0.3589	0.4028	0.013	Reference group		Reference group
T-T-C-C-G-G-T-A	0.0603	0.0926	0.265	0.85 (0.46–1.57)	0.609	1.00 (0.41–2.45)	0.983
A-A-C-C-G-G-T-A	0.0525	0.0861	0.066	0.83 (0.43–1.64)	0.599	0.85 (0.47–1.81)	0.617
A-T-C-C-G-C-T-A	0.0682	0.0467	0.192	2.19 (1.09–4.39)	0.028	1.88 (0.96–3.37)	0.174
A-T-C-T-G-C-T-A	0.0672	0.0502	0.003	1.78 (0.95–3.33)	0.072	2.72 (1.24–5.78)	0.004
A-T-C-C-A-G-T-A	0.0458	0.0501	0.658	0.85 (0.41–1.79)	0.672	0.83 (0.33–1.77)	0.606
A-A-C-C-G-G-T-G	0.0280	0.0525	0.201	0.56 (0.24–1.32)	0.187	0.73 (0.25–1.99)	0.545

Abbreviations: OR, odds ratio; 95% CI, 95% confidence interval. For each haplotype, alleles are arranged in order of rs199514452, rs201540428, rs201614260, rs17879702, rs17880292, rs17879599, rs17424145 and rs35445101.

^*P was calculated in a multivariate binary Logistic regression model after adjusting for age, gender, smoking, drinking and hepatitis infection.