Table 1. Major features of the included studies.

Study	Year	Study location	Number of patients	Races	Malignant disease	Technology	Detected sample	Antibody	Staining patterns	Cut-off	CD147 expression(%)
Zheng [16]	2006	Japan	234	Asian	Gastric cancer	TMA and IHC	Tissue	Mouse anti-EMMPRIN	Membrane and cytoplasm	P>5%	64.96%
Zhang [17]	2012	China	436	Asian	Gastric cancer	TMA and IHC	Tissue	Mouse monoclonal antibody	Membrane	S≥4	66.51%
Chu [18]	2014	China	223	Asian	Gastric cancer	IHC	Tissue	Mouse anti-human CD147 monoclonal antibody	Membrane and cytoplasm	S≥1	59.64%
Boye [19]	2012	Norway	277	Caucasian	Colorectal cancer	IHC	Tissue	Goat polyclonal anti-EMMPRIN antibody	Membrane and cytoplasm	P≥5%	71.48%
Zhu [20]	2013	China	328	Asian	Colorectal cancer	TMA and IHC	Tissue	Mouse anti-human HAb18G/CD147 monoclonal antibody	Membrane and cytoplasm	S≥1	63.11%
Stenzinger [21]	2011	Germany	285	Caucasian	Colorectal cancer	TMA and IHC	Tissue	Rabbit polyclonal antibody	Membrane and cytoplasm	S>1	49.82%
Jung [22]	2011	Korea	210	Asian	Colorectal cancer	TMA and IHC	Tissue	Monoclonal antibody	Membrane and cytoplasm	S≥3	62%

TMA, tissue microarray; IHC, immunohistochemistry; P, proportion of stained tumor cells; S, scores for intensity and proportion of stained tumor cells.