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. 2016 Nov 8;7(49):81110–81122. doi: 10.18632/oncotarget.13212

Figure 6. Combination of anti-TNF-α treatments with chemotherapy resulted in better anti-cancer responses in PDAC xenograft mouse model.

Figure 6

(A) Tumor growth curve showed that addition of anti-TNF-α antibodies further delayed tumor growth based on chemotherapy. (B) Anti-TNF-α treatments synergized with chemotherapy to prolong survival time of PDAC xenograft mouse model. (C) HE staining, TNF-α expression, cleaved-Caspase-3 expression, and Ki-67 expression were analyzed in each group. Less TNF-α expression and more cleaved-Caspase-3 expression were found in anti-TNF-α treatments groups.