Table 1. Correlation between USP33 expression and clinicopathologic characteristics of CRCLM patients.
Variable | n | USP33 expression in primary tumor | P | USP33 expression in CRCLM | P | ||
---|---|---|---|---|---|---|---|
Low (N = 86) | High (N = 53) | Low (N = 54) | High (N = 85) | ||||
Gender | 0.672 | 0.314 | |||||
Female | 52 | 31 | 21 | 23 | 29 | ||
Male | 87 | 55 | 32 | 31 | 56 | ||
Age (year) | 0.700 | 0.796 | |||||
< 50 | 42 | 27 | 15 | 17 | 25 | ||
≥ 50 | 97 | 59 | 38 | 37 | 60 | ||
Primary tumor location | 0.664 | 0.388 | |||||
Colon | 86 | 52 | 34 | 31 | 55 | ||
Rectum | 53 | 34 | 19 | 23 | 30 | ||
Primary tumor differentiation | 0.771 | 0.256 | |||||
Poor | 16 | 11 | 5 | 9 | 7 | ||
Moderate | 102 | 63 | 39 | 36 | 66 | ||
Well | 21 | 12 | 9 | 9 | 12 | ||
Primary tumor staging | 0.002* | 0.001* | |||||
T1–T2 | 24 | 8 | 16 | 2 | 22 | ||
T3–T4 | 115 | 78 | 37 | 52 | 63 | ||
Preoperative CEA level | 0.754 | 0.222 | |||||
< 100 ng/mL | 81 | 51 | 30 | 30 | 56 | ||
≥ 100 ng/mL | 58 | 35 | 23 | 24 | 29 | ||
Distribution of CRCLM | 0.808 | 0.682 | |||||
Unilobar | 98 | 60 | 38 | 37 | 61 | ||
Bilobar | 41 | 26 | 15 | 17 | 24 | ||
No. of CRCLM | 0.002* | 0.269 | |||||
< 3 | 90 | 47 | 43 | 38 | 52 | ||
≥ 3 | 49 | 39 | 10 | 16 | 33 | ||
Largest diameter of CRCLM | 0.647 | 0.678 | |||||
< 5 cm | 69 | 44 | 25 | 28 | 41 | ||
≥ 5 cm | 70 | 42 | 28 | 26 | 44 | ||
Differentiation of CRCLM | 0.188 | 0.713 | |||||
Poor | 6 | 4 | 2 | 3 | 3 | ||
Moderate | 120 | 77 | 43 | 47 | 73 | ||
Well | 13 | 5 | 8 | 4 | 9 | ||
Resection margin of CRCLM | 0.256 | 0.888 | |||||
R1 | 15 | 7 | 8 | 5 | 10 | ||
R0, 1–10 mm | 87 | 58 | 29 | 34 | 53 | ||
R0, > 10 mm | 37 | 21 | 16 | 15 | 22 | ||
LN metastasis | 0.001* | < 0.001* | |||||
Negative | 36 | 14 | 22 | 5 | 31 | ||
Positive | 103 | 72 | 31 | 49 | 54 | ||
Extrahepatic metastasis | 0.701 | 0.087 | |||||
Negative | 120 | 75 | 45 | 50 | 70 | ||
Positive | 19 | 11 | 8 | 4 | 15 |
Abbreviations: CRCLM: liver metastases of colorectal cancer; CEA: carcinoembryonic antigen; T1: stage I; T2: stage II; T3: stage III; T4: stage IV.