Table 4. Multivariate Cox-regression analysis of overall survival and disease-free survival.
| OS | |||
|---|---|---|---|
| Variable | HR | 95% CI | P value |
| Distribution of CRCLM | 1.988 | 1.296 − 3.049 | 0.002* |
| No. of CRCLM | 1.923 | 1.265 − 2.923 | 0.002* |
| Largest diameter of CRCLM | 1.550 | 1.049 − 2.291 | 0.028* |
| Differentiation of CRCLM | 0.836 | 0.489 − 1.431 | 0.514 |
| Resection margin of CRCLM | 0.592 | 0.397 − 0.882 | 0.010* |
| LN metastasis | 1.658 | 1.005 − 2.736 | 0.048* |
| Extrahepatic metastasis | 2.238 | 1.282 − 3.904 | 0.005* |
| USP33 expression in primary tumor | 1.355 | 0.887 − 2.068 | 0.160 |
| USP33 expression in CRCLM | 1.653 | 1.113 − 2.453 | 0.013* |
| DFS | |||
| Variable | HR | 95% CI | P value |
| Primary tumor staging | 1.430 | 0.770 − 2.655 | 0.257 |
| Distribution of CRCLM | 1.574 | 1.019 − 2.432 | 0.041* |
| No. of CRCLM | 2.128 | 1.409 − 3.216 | < 0.001* |
| Largest diameter of CRCLM | 1.513 | 1.020 − 2.242 | 0.039* |
| Differentiation of CRCLM | 0.814 | 0.486 − 1.365 | 0.436 |
| Resection margin of CRCLM | 0.638 | 0.425 − 0.959 | 0.031* |
| LN metastasis | 2.425 | 1.443 − 4.075 | 0.001* |
| USP33 expression in CRCLM | 1.596 | 1.055 − 2.412 | 0.027* |
Abbreviations: OS: overall survival; DFS: disease-free survival; HR: hazard ratio; CI: confidence interval; CRCLM: liver metastases of colorectal cancer.