Table 1. Characteristics of 24 aberrant methylated genes between carcinoma tissues and adjacent tissues in HCC.
| Gene | Studies (n) | Overall OR (95% CI) | I2 | P value | Carcinoma tissues/adjacent tissues |
|---|---|---|---|---|---|
| p16 | 43 | 5.10 [3.81, 6.84] | 68% | < 0.00001 | 2185/2081 |
| RASSF1A | 28 | 6.70 [4.83, 9.30] | 53% | < 0.00001 | 1414/1265 |
| GSTP1 | 20 | 6.81 [5.39, 8.62] | 35% | < 0.00001 | 1011/883 |
| p14 | 17 | 2.67 [1.26, 5.64] | 77% | 0.01 | 911/717 |
| APC | 15 | 5.14 [3.18, 8.30] | 71% | < 0.00001 | 888/762 |
| RUNX3 | 13 | 19.99 [10.06, 39.72] | 68% | < 0.00001 | 1025/998 |
| SOCS1 | 13 | 3.47 [1.80, 6.71] | 82% | 0.0002 | 767/674 |
| CDH1 | 12 | 2.31 [1.13, 4.74] | 82% | 0.02 | 575/533 |
| p15 | 12 | 2.03 [1.23, 3.36] | 51% | 0.006 | 535/446 |
| MGMT | 10 | 1.66 [0.64, 4.28] | 79% | 0.3 | 560/470 |
| PRDM2 | 9 | 12.33 [8.54, 17.81] | 40% | < 0.00001 | 470/452 |
| WIF1 | 8 | 6.53 [3.33, 12.80] | 71% | < 0.00001 | 654/506 |
| DAPK1 | 6 | 1.03 [0.64, 1.66] | 19% | 0.91 | 271/231 |
| SFRP1 | 5 | 3.95 [1.91, 8.14] | 67% | 0.0002 | 304/275 |
| RARβ | 5 | 5.27 [1.53, 18.10] | 62% | 0.008 | 276/170 |
| IGF2 | 5 | 0.18 [0.02, 1.55] | 86% | 0.12 | 160/200 |
| p73 | 5 | 6.15 [3.09, 12.24] | 48% | < 0.00001 | 275/169 |
| hMLH1 | 4 | 5.10 [2.20, 11.85] | 0% | 0.0001 | 251/182 |
| DLC1 | 3 | 17.30 [6.71, 44.58] | 0% | < 0.00001 | 206/200 |
| p53 | 3 | 5.12 [1.27, 20.59] | 16% | 0.02 | 107/107 |
| SPINT2 | 3 | 18.38 [3.81, 88.61] | 71% | 0.0003 | 130/130 |
| RB1 | 3 | 7.33 [0.58, 92.08] | 64% | 0.12 | 123/123 |
| OPCML | 3 | 1.93 [1.20, 3.11] | 0% | 0.006 | 213/144 |
| WT1 | 3 | 5.08 [2.41, 10.69] | 0% | < 0.0001 | 113/113 |