Table 2. Characteristics of 17 aberrant methylated genes between carcinoma tissues and normal tissues in HCC.
| Gene | Studies (n) | Overall OR (95% CI) | I2 | P value | Carcinoma tissues/normal tissues |
|---|---|---|---|---|---|
| p16 | 31 | 13.41 [9.18, 19.59] | 13% | < 0.00001 | 1415/399 |
| RASSF1A | 21 | 43.70 [26.92, 70.96] | 37% | < 0.00001 | 900/341 |
| APC | 14 | 17.20 [5.75, 51.41] | 73% | < 0.00001 | 727/217 |
| GSTP1 | 13 | 13.56 [5.52, 33.29] | 57% | < 0.00001 | 646/199 |
| CDH1 | 10 | 4.93 [2.70, 8.99] | 17% | < 0.00001 | 469/111 |
| p15 | 9 | 5.48 [2.54, 11.79] | 0% | < 0.0001 | 382/70 |
| RUNX3 | 8 | 31.16 [12.24, 79.31] | 0% | < 0.00001 | 549/152 |
| SOCS1 | 8 | 9.73 [2.85, 33.27] | 66% | 0.0003 | 474/118 |
| MGMT | 8 | 10.84 [3.46, 33.91] | 36% | < 0.0001 | 458/93 |
| PRDM2 | 8 | 24.86 [10.44, 59.17] | 0% | < 0.00001 | 422/116 |
| SFRP1 | 7 | 13.97 [5.28, 36.92] | 0% | < 0.00001 | 372/91 |
| DAPK1 | 7 | 5.32 [2.38, 11.91] | 0% | < 0.0001 | 328/77 |
| p14 | 6 | 6.42 [1.54, 26.69] | 56% | 0.01 | 317/57 |
| RARβ | 5 | 7.37 [1.79, 30.39] | 14% | 0.006 | 230/54 |
| IGF2 | 5 | 0.48 [0.02, 9.59] | 89% | 0.63 | 207/36 |
| hMLH1 | 3 | 3.24 [0.18, 58.10] | — | 0.42 | 204/34 |
| p73 | 3 | 27.59 [4.87, 156.35] | 0% | 0.0002 | 174/27 |
The heterogeneity of hMLH1 gene methylation was not applicable, because two of three case-control studies were not estimable.