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. 2016 Oct 28;7(49):81435–81451. doi: 10.18632/oncotarget.12963

Figure 2. RHOA expression analysis shows difference in Asian vs. Caucasian.

Figure 2

A. RHOA mRNA expression levels, by cancer stage in both Asian and Caucasian races, showed RHOA expression to significantly associate (p-value 0.032 by one-way ANOVA) with Asian GC disease stages, but not in Caucasians. In particular, RHOA up-regulation in Stage I, compared to normal, is shown. B. molecular subtypes between TCGA Asian and Caucasian GC patients. By using cBioPortal (data version: Stomach Adenocarcinoma (TCGA, Nature 2014)), the proportions between the two races, in terms of molecular subtypes, were not statistically different. C. RHOA mutation between TCGA Asian and Caucasian datasets. By using cBioPortal (as above), the proportions between the two racial groups, in terms of RHOA mutations, were not statistically different. D. RHOA mutations, as compared between TCGA Asian and Caucasian data, according to Lauren class. Diffuse type was bolded to show enrichment of mutation compared to intestinal and mixed. As shown, the proportions between the two ethnicities in terms of RHOA mutations and Lauren class were not statistically different.