Table 1. Characteristics of studies included for meta-analysis of miRNA expression in ovarian cancer.
Author (year) | Country | Ethnicity | Period | No. of sample (T/N) | Cancer subtype | Sample source | Method | Total miRNAs | Cut-off criteria |
---|---|---|---|---|---|---|---|---|---|
Iorio(2007) [17] | USA | Caucasian | NA | 69/15 | 31 serous, 8 endometrioid, 4 clear cell, 9 poorly differentiated, 1 mucinous carcinoma. | Frozen tissue | Microarray | 235 | p<0.01 and FC>3 |
Nam(2008) [18] | Korea | Asian | 2000.12-2003.9 | 20/8 | 20 serous ovarian carcinoma | Frozen tissue | Microarray | 314 | FC>2 |
Dahiya (2008) [19] | USA | Caucasian | NA | 34/1a | 31 serous, 2 clear cell, 1 borderline carcinoma | Frozen tissue | Microarray | 462 | FC>2 |
Yang (2008) [20] | USA | Caucasian | NA | 10/10a | 10 serous ovarian carcinomas | Frozen tissue | Microarray | 515 | FC>1 |
Wyman (2009) [21] | USA | Caucasian | NA | 33/4a | 19 serous, 4 clear cell 10 endometrioid carcinoma | Frozen tissue | Sequencing | 498 | FC>4 |
Resnick (2009) [22] | USA | Caucasian | NA | 28/15 | 17 serous, 6 clear cell, 3 endometrioid, 2 mucinous carcinoma | Frozen tissue | Microarray | 365 | FC>1.5 |
Kim (2010) [23] | Korea | Asian | NA | 54/49b | 29 serous, 11 mucinous, 7 endometrioid, 7 clear cell carcinoma | Frozen tissue | Microarray | 739 | p<0.01 |
Elgaaen (2014)a [24] | Norway | Caucasian | 2003-2012 | 35/9 | 35 high-grade serous carcinoma | Frozen tissue | Microarray | 1105 | p<0.01 |
Elgaaen (2014)b [24] | Norway | Caucasian | 2003-2012 | 19/9 | 19 clear cell carcinoma | Frozen tissue | Microarray | 1105 | p<0.01 |
Dong (2014) [25] | China | Asian | 2008.4~2012.7 | 5/5 | 5 high-grade serous carcinoma | Frozen tissue | Microarray | 2064 | FC>2 and p<0.05 |
LI (2014) [26] | China | Asian | NA | 100/50 | 100 serous carcinoma | PPFE | Microarray | 739 | FC>2 |
Shapira (2014) [27] | USA | Caucasian | NA | 42/36 | 42 serous carcinoma | Plasma | Microarray | 754 | FC>2 |
Wang (2014) [28] | China | Asian | NA | 48/15 | 29 serous, 6 mixed epithelial, 6 endometrioid, 1 adenocarcinoma, 4 clear cells, 2 mucinous carcinoma | Frozen tissue | High throughput PCR | 1757 | FC>1.5 |
Ibrahim (2015) [29] | Malaysia | Asian | 2006-2013 | 22/22 | 22 serous ovarian carcinoma | Frozen tissue | Microarray | 85 | FC>2 |
Immortalized human ovarian surface epithelial cells were used as control.
Benign tumors were used as control.
FFPE, formalin-fixed paraffin-embedded; FC, fold change; NA, not available.