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. 2016 Nov 7;7(49):81634–81644. doi: 10.18632/oncotarget.13155

Figure 1. AEG-1 knockdown inhibited migration and invasion in colon cancer cell lines.

Figure 1

Stable AEG-1 knockdown and negative control cells of the cell lines SW480, SW620 and HCT116 were seeded in FBS free medium in migration chambers or in matrigel invasion chamber respectively, and were placed in 24 well plates with FBS containing medium. After 24 h, migration and invasion were determined by counting the cells migrated or invaded into the membrane. A. Stable AEG-1 knockdown cell lines had a lower cell migration compared to the control cell lines SW480 (0.92 fold; p=0.052), SW620 (0.60 fold; p=0.011) and HCT116 (0.55 fold; p=0.049). B. Stable AEG-1 knockdown cell lines had a lower cell invasion compared to the control cell lines SW480 (0.78 fold; p=0.046), SW620 (0.15 fold; p=0.0008) and HCT116 (0.53 fold; p=0.013). Data are presented as the ratios between the AEG-1 knockdown and the negative control for each cell line. NC: negative control; AEG-1: AEG-1 knockdown. Error bars represent mean ± SD. All the experiments were performed in duplicates at least three times.