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. 2016 Nov 7;7(49):81634–81644. doi: 10.18632/oncotarget.13155

Figure 2. Radiation enhanced migration and invasion of colon cancer cell lines.

Figure 2

The SW480, SW620 and HCT116 cell lines were seeded in FBS containing medium in migration chamber or in matrigel invasion chamber respectively, placed in 24 well plates with FBS containing medium and either irradiated with 7.5 Gy or unirradiated as a control. After 24 h, migration and invasion were determined by counting the cells migrated or invaded into the membrane. A. Radiation-enhanced migration was observed in all the three cell lines, SW480 (1.81 fold; p=0.001), SW620 (1.66 fold; p=0.01), and HCT116 (1.65 fold; p=0.03). B. Radiation-enhanced invasion was observed in the SW480 cell line (2.39 fold: p=0.047), a trend in the SW620 (1.33 fold; p=0.26), but not in the HCT116 cells (0.89 fold; p=0.31). Data are presented as the ratios between 7.5 Gy and 0 Gy for each cell line. NC: negative control; AEG-1: AEG-1 knockdown. Error bars represent mean ± SD. All the experiments were performed in duplicates at least three times.