Table 7. IKK and NIK Inhibitors as Anti-MM Agents.

Compound	Route	Structure	Kinase(s) Inhibited (IC50 in nM)a	References
Angelicin* (AS602868)	Oral		IKKbeta (20)	[418, 419]
BAY 11-7082‡	NA		IKKalpha/beta (10000c)	[420]
BAY 11-7085‡	NA		IKKalpha/beta (10000c)	[194, 421]
BMS-345541†	Oral		IKKbeta (300)	[193, 422]
DETT	Oral		IKKalpha/beta (NA)	[423]
MLN 120B*	Oral		IKKbeta (45b)	[424]
PS-1145*	Oral		IKKbeta (88)	[193, 425]
AM-0216*	NA		NIK (2b)	[426]
AM-0561*	NA		NIK (0.3b)	[426]

NA = Information unavailable;

^*ATP-competitive inhibitor;

^†allosteric inhibitor;

^‡irreversible inhibitor;

^aas determined in cell-free assays, unless otherwise indicated;

^bK_i in nM;

^chuman umbilical vein endothelial cells (HUVEC)