2.

Types of EGFR uncommon mutation (N=128)

Uncommon EGFR mutation	Case No.	%
EGFR, epidermal growth factor receptor; 19 del, exon 19 deletion.
Single mutation	96	75.0
G719X	38	29.7
S768I	23	18.0
Exon 20 insertion	17	13.3
L861Q	16	12.5
T790M (primary mutation)	1	0.8
T725T synonymous mutation	1	0.8
Complex mutation	32	25.0
Sensitive+sensitive mutation	2	1.6
L858R + 19 del	2	1.6
Sensitive + uncommon mutation	15	11.7
L858R +De novo T790M	7	5.5
L858R + S768I	4	3.1
L858R + L861Q	1	0.8
19 del + G719X	1	0.8
19 del +De novo T790M	1	0.8
19 del + L861Q	1	0.8
Uncommon + uncommon mutation	15	11.7
G719X + S768I	9	7.0
G719X +De novo T790M	3	2.3
G719X + E709A	2	1.6
G719X + L861Q	1	0.8