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MAGI1 inhibited matrix metalloproteinase (MMP) expression and epithelial-mesenchymal transition (EMT) progression by blocking mitogen-activated protein kinases/extracellular signal-regulated kinase (MAPK/ERK) signaling pathway in gastric cancer (GC) cells. (A, B, C) MAGI1 knockdown activated ERK but not JNK or P38 in AGC cells; (D) The expression of MMPs and EMT molecules detected by reverse transcription-polymerase chain reaction (RT-PCR) in AGS cells.
