3.

Multiple Cox regression analysis of survival after first TACE and HAIC

Variables	Multivariate analysis		P
	HR	95% CI
TACE, transarterial chemoembolization; HAIC, hepatic arterial infusion chemotherapy; CA, carbohydrate antigen; CEA, carcinoembryonic antigen; PR, partial response; SD, stable disease; PD, progressive disease; HR, hazard ratio; 95% CI, 95% confidence interval; NA, not available.
Serum CA19-9 (U/mL) (≥37vs. <37)	2.093	1.392–3.147	<0.001
Serum CEA (U/mL) (≥5vs. <5)	0.935	0.530–1.650	0.818
Serum CA72-4 (U/mL) (≥6.7vs. <6.7)	1.062	0.667–1.691	0.799
Histology (poorlyvs. well and moderate)	0.704	0.408–1.216	0.208
Response to TACE			<0.001
PR	0.207	0.122–0.353	<0.001
SD	0.256	0.154–0.427	<0.001
PD	1	1	NA
Other local treatment (combinedvs. uncombined)	0.439	0.268–0.721	0.001