Table 4.
Differential pathway-phylum combinations between cecal and fecal metaproteome.
| Pathway | Phylum | Adjusted p-value | Mean CC/F fold-change (±SEM) |
|---|---|---|---|
| Tetrahydrofolate interconversion | Firmicutes | 1.5 × 10-3 | 6.00 ±3.80 |
| IMP biosynthesis via de novo pathway | Firmicutes | 4.7 × 10-16 | 4.92 ±1.51 |
| Diglucosyl-diacylglycerol biosynthesis | Firmicutes | 1.1 × 10-19 | 4.62 ±1.11 |
| Pentose phosphate pathway | Firmicutes | 1.0 × 10-4 | 3.86 ±1.57 |
| Starch degradation | Ascomycota | 1.4 × 10-5 | 3.83 ±2.13 |
| Pyruvate fermentation | Firmicutes | 1.6 × 10-6 | 3.53 ±1.24 |
| 1,2-Propanediol degradation | Firmicutes | 1.0 × 10-12 | 3.22 ±0.89 |
| Galactarate degradation | Firmicutes | 4.4 × 10-12 | 3.18 ±1.06 |
| (R)-Mevalonate biosynthesis | Firmicutes | 6.5 × 10-4 | 2.84 ±0.87 |
| Propanoyl-CoA degradation | Firmicutes | 4.9 × 10-6 | 2.67 ±0.60 |
| L-Tryptophan degradation via pyruvate pathway | Firmicutes | 2.7 × 10-4 | 2.36 ±0.22 |
| L-Isoleucine biosynthesis | Firmicutes | 9.4 × 10-17 | 2.23 ±0.32 |
| Glycogen biosynthesis | Firmicutes | 4.0 × 10-9 | 2.23 ±0.31 |
| UMP biosynthesis via salvage pathway | Firmicutes | 5.2 × 10-14 | 2.17 ±0.67 |
| Starch degradation | Proteobacteria | 2.3 × 10-15 | 2.17 ±0.33 |
| L-Arabinose degradation via L-ribulose | Firmicutes | 1.1 × 10-14 | 2.02 ±0.25 |
| Glycolysis | Firmicutes | 2.4 × 10-13 | 1.98 ±0.28 |
| Butanoate metabolism | Firmicutes | 5.5 × 10-22 | 1.87 ±0.06 |
| Glycolysis | Bacteroidetes | 2.9 × 10-10 | -1.79 ±0.22 |
| Tricarboxylic acid cycle | Bacteroidetes | 1.8 × 10-17 | -1.80 ±0.12 |
| Xyloglucan degradation | Bacteroidetes | 1.1 × 10-9 | -2.31 ±0.36 |
| Selenocysteinyl-tRNA(Sec) biosynthesis | Bacteroidetes | 1.8 × 10-11 | -2.44 ±0.29 |
| L-Lysine biosynthesis via DAP pathway | Bacteroidetes | 4.9 × 10-8 | -2.60 ±0.31 |
| Starch degradation | Bacteroidetes | 6.3 × 10-19 | -2.74 ±0.42 |
| 2-Dehydro-3-deoxy-D-gluconate degradation | Bacteroidetes | 3.4 × 10-18 | -3.00 ±0.76 |
| L-Isoleucine biosynthesis | Bacteroidetes | 1.4 × 10-8 | -3.04 ±0.69 |
| IMP biosynthesis via de novo pathway | Bacteroidetes | 5.2 × 10-7 | -3.20 ±1.20 |
| 2-Deoxy-D-ribose 1-phosphate degradation | Bacteroidetes | 3.3 × 10-21 | -3.37 ±0.29 |
| Lipid IV(A) biosynthesis | Bacteroidetes | 2.0 × 10-20 | -4.44 ±1.56 |
| Urea degradation | Bacteroidetes | 3.3 × 10-25 | -5.67 ±1.09 |
| Purine nucleoside salvage | Bacteroidetes | 2.2 × 10-24 | -7.22 ±2.69 |
| Oxalate degradation | Bacteroidetes | 4.9 × 10-26 | -22.15 ±8.10 |