FIGURE 5.
Amino acid sequence alignment of HMPV strains. Aligned amino acid sequences derived from the HMPV G genes of 15 A2b180nt-dup HMPV strains, the hypothetical ancestral strain (Ancestor), and a representative classical A2b strain (P7015) are shown. The region between amino acid (aa) 1–30 is the cytoplasmic tail (CT) domain, and the region between aa 31–53 is the transmembrane (TM) domain. The remaining region is the extracellular ectodomain (EE). The 1st-180nt and 2nd-180nt regions are shown in green and pink boxes, respectively. The amino acid sequence of the hypothetical ancestral strain was predicted by constructing a consensus sequence of all 15 A2b180nt-dup HMPV strains. Dots indicate amino acids identical to those of the hypothetical ancestral strain. Hyphens in yellow boxes indicate gaps in the sequence.